Blade is a one-of-a-kind individual with the power of vampires but remaining a man. Once he got into the blood a small particle of venom of vampires, so with the help of a special serum he can still restrain the beast inside himself and use his power. Realizing what a danger for the world is represented by vampires, Blade stepped on the warpath with them. But gradually the serum loses its properties and the guy feels the approach of its end. But before that, he must take revenge on his offender Deacon Frost and kill as many non-humans as possible. There comes a time when he realizes that his life can become the payment in this war and he decides to enter into the last confrontation. Gathering all his skills and knowledge together, he goes to the very den of the enemy to take the decisive battle there.